Pressure-test a target
Examine which routes remain available when the target is blocked and where the therapeutic rationale needs further testing.
Computational biology for drug development
Escape is a design input.
Escape is a design input.
Treat it like one.
A target rationale says why the node matters. It does not say what still drives the phenotype once that node is blocked.
PROEIDIS ranks the routes around the block, with the evidence for each, before the strategy is locked.
Test the target against its escape routes. Build combination strategies around a named mechanism.
01The problem
A blocked target can leave the disease an exit.
Target engagement answers one question. What sustains disease activity after the block answers another.
That second question belongs in target selection and combination design — before the next major development commitment.
02The value
Put escape logic into the development decision.
Develop a combination rationale
Connect a proposed second intervention to a specific escape route and its supporting evidence.
Focus the next experiment
Use the route-level reasoning to define what to test, rather than starting with an open-ended screen.
03The method
A rationale your scientists can challenge.
Follow the reasoning from the blocked target through the ranked escape routes to the supporting biological evidence.
The ranked routes are mechanistic hypotheses for experimental testing. Each is linked to the biological evidence supporting it.
04Contact
Bring the target. Start with what survives the block.
We welcome early scientific collaborations with pharmaceutical, biotech and translational research teams.